The high co-morbidity between bipolar disorder and alcohol dependence may h
ave different explanations, one of them being the existence of common genet
ic factors for the two disorders. Several candidate genes may be involved b
ut the genes acting in the dopaminergic pathway may be more specifically in
volved. We have thus tested the role of the gene encoding the D2 dopamine r
eceptor (Taql Al allele) in the potentially shared vulnerability to alcohol
dependence and bipolar disorder. One hundred and twenty-two French (for at
least two generations) patients were recruited on the basis of hospital or
outpatient files and were interviewed with the DIGS. The Al allele frequen
cies were compared between four groups, namely, with bipolar patients and c
o-morbid alcohol dependence (N = 21), with bipolar patients without alcohol
morbidity (N = 31), with alcohol dependence without mood disorder (N = 35)
and unaffected controls (N = 35). The Hardy Weinberg equilibrium for the D
RD2 Taql Al genotypes was respected for the sample as a whole, and for each
subsample. We observed that 42.9% of control subjects have at least one Al
allele, a frequency which is not significantly different from the one obse
rved in the affected sample as a whole (39.1%), neither from patients with
alcohol dependence (37.1%), patients with bipolar disorder (48.4%) nor pati
ents with alcohol dependence and bipolar disorder (28.6%). The regression a
nalysis based on the three variables (bipolar disorder, alcohol dependence
and interaction between these two disorders) does not explain the presence
of the Al allele of the DRD2 gene. We thus found no evidence for a signific
ant role of the Al allele of the D2 dopamine receptor gene in the specific
association between bipolar disorder and alcohol dependence in our sample.
(C) 2000 Editions scientifiques et medicales Elsevier SAS.