Tss (Tail-short Shionogi), a new short tail mutation found in the BALB/cMsstrain, maps quite closely to the tail-short (Ts) locus on mouse chromosome 11

A spontaneous morphological mutation characterized by a short and kinky fai l (Tail-short Shionogi: Tss) was observed in a BALB/cMs mouse breeding colo ny. The inheritance mode of the Tss mutation is semi-dominant, and homozygo tes (Tss/Tss) are probably embryonic lethal. The viability of the Tss/+ het erozygotes appear to be influenced by the mating partner: 47.1% of the (BAL B/cMs-Tss/+ x C57BL/6J)F1 embryos were the mutant phenotype, whereas there were no (BALB/cMs-Tss/+ x A/J)F1 embryos with the mutant phenotype. The Tss locus was mapped by linkage analysis between microsatellite markers D11Mit 128 and D11Mit256 on mouse Chromosome 11. These results suggest that the Ts s mutation is a new allele on the Tail-short (Ts) locus.