Reactions of N-phthalylamino acid chlorides with trialkyl phosphites

Reaction of commercially available trialkyl phosphites with N-phthalylamino acids gave mixtures of seven products, whereas the same reaction carried o ut with pure triethyl phosphite yielded only the desire 2-(N-phthalylamino) -1-oxoalkanephosphonates. These compounds underwent rearrangement to the sa me types of products that were obtained with the commercial phosphites. Thi s latter series of reactions was promoted by the presence of dialkyl phosph ites. (C) 2000 John Wiley & Sons, Inc.