N. Young et al., USE OF SPIRAL AND NON-SPIRAL COMPUTED-TOMOGRAPHY ARTERIAL PORTOGRAPHYIN THE DETECTION OF POTENTIALLY MALIGNANT LIVER MASSES, Journal of gastroenterology and hepatology, 12(5), 1997, pp. 385-391
The present study assesses the usefulness of computed tomography (CT)
arterial portography (CTAP) in detecting and defining the number and a
natomy of potentially malignant liver lesions. One hundred and one adu
lts studied in 1993 and 1994 were retrospectively reviewed, including
patients with primary or secondary rumours for possible resection and
patients with non-hepatic malignancies in whom the detection of liver
metastases would preclude surgery. Twenty-three patients underwent non
-spiral CT studies and 78 had studies on a spiral unit, with 22 of the
se having single phase and 56 having dual phase studies to overcome ar
tefact problems. The relationship between lesion size and detection se
nsitivity is critical. On non-spiral studies, the overall lesion detec
tion sensitivity and positive predictive value was 69 and 90%, respect
ively. Detection sensitivity was 100 and 20% for lesions >1 cm and <1
cm, respectively On single phase spiral CTAP the overall detection sen
sitivity and positive predictive value was 80and 66%, respectively. De
tection sensitivity for lesions >1 cm and <1 cm was 100 and 0%, respec
tively. On dual phase spiral CTAP the overall detection sensitivity an
d positive predictive value was 76 and 71%, respectively. For lesions
>1 cm and <1 cm the sensitivity was 81 and 55%, respectively. Eighteen
patients with non-hepatic malignancies with unsuspected metastatic sp
read did not proceed to major surgery because of liver metastases dete
cted on CTAP. Perfusion artefacts occurred in 30 and 64% of non-spiral
and of initial portal venous spiral CTAP studies, respectively. By us
ing the double-phase technique, these artefacts were substantially dim
inished. In conclusion, CTAP is a valuable tool for assessing the pres
ence, site and size of possible liver rumours and confers a benefit ev
en when previous ultrasound and conventional CT have already been used
. In addition, CTAP has a lower limit of useful resolution of approxim
ately I cm. Perfusion artefacts can be reduced by a dual phase protoco
l.