The CRIB (Clinical Risk Index for Babies) score and neurodevelopmental impairment at one year corrected age in very low birth weight infants

Objective: To assess the ability of the Clinical Risk Index for Babies (CRI B) to predict long-term neurodevelopmental impairment in very low birth wei ght (VLBW) infants. Design: Single-center cohort study. Setting: Tertiary neonatal care hospital and follow-up clinic. Patients: Four hundred fifty-five VLBW infants consecutively admitted from 1992 to 1997 inclusive. Measurements and results: Calculations of CRIB scores from birth weight, ge stational age, the presence of congenital malformations, worst base excess, maximum and minimum appropriate fraction of inspired oxygen (FIO2) during the first 12 h of life was possible in 430 infants. Three hundred eighty-si x infants survived until discharge (89 %) and 352 (91 %) were examined at 1 year corrected age using the Griffiths scales of mental development. Major neurodevelopmental impairment (general quotient < 2 standard deviations be low average) was observed in 76 infants (22 %). CRIB scores and the individ ual CRIB components differed significantly between infants with and those w ithout neurodevelopmental impairment. By logistic regression analysis, CRIB scores and minimum FIO2 were independent predictors of death, while CRIB a nd maximum FIO2 were independently associated with neurodevelopmental impai rment. For combined poor outcome (death or impairment), CRIB, minimum and m aximum FIO2 were independent predictors. In predicting major neurodevelopme ntal impairment, the area under the receiver operating characteristic curve for CRIB (0.703 +/- 0.035) did not differ significantly from that of birth weight (0.697 +/- 0.035) or any other CRIB component. Conclusion: While high CRIB scores are associated with major neurodevelopme ntal impairment, the CRIB score is of limited value for stratification in r andomized trials or for adjustments in comparing performance between hospit als with neurodevelopmental impairment as the main outcome measure.