Morphobiochemical state of liver and serum albumins system in conditions of tetrachloromethane intoxication and introduction of antihypoxants, antioxidants, and actoprotectors

Organism intoxication with tetrachloromethane induces a complex of transfor mations in the liver and serum albumins system manifested in the liver as n ecroses in the central lobe, dilatation of sinus capillaries and blood stas is in them, increased content of total water, and changed magneto-relaxatio n properties indicating decreased structurization of water. The system of s erum albumins shows decreased total concentration of albumins in the serum, decreased constant of 1-(phenylamino)-8-sulfonaphthalene probe binding, in creased mean number of probe binding per albumin molecule, and increased ac cessibility of probe in the protein-probe complex for the quencher indicati ng changed type of interaction between the protein and fluorescent probe. I ntroduction of a antihypoxant, antioxidant, or actoprotector has a positive effect on the condition of the liver and serum albumins system: The studie d indices are nearly completely normalized.