Morphobiochemical state of liver and serum albumins system in conditions of tetrachloromethane intoxication and introduction of antihypoxants, antioxidants, and actoprotectors
Tk. Dubovaya et al., Morphobiochemical state of liver and serum albumins system in conditions of tetrachloromethane intoxication and introduction of antihypoxants, antioxidants, and actoprotectors, IAN BIOL, (2), 2000, pp. 158-163
Organism intoxication with tetrachloromethane induces a complex of transfor
mations in the liver and serum albumins system manifested in the liver as n
ecroses in the central lobe, dilatation of sinus capillaries and blood stas
is in them, increased content of total water, and changed magneto-relaxatio
n properties indicating decreased structurization of water. The system of s
erum albumins shows decreased total concentration of albumins in the serum,
decreased constant of 1-(phenylamino)-8-sulfonaphthalene probe binding, in
creased mean number of probe binding per albumin molecule, and increased ac
cessibility of probe in the protein-probe complex for the quencher indicati
ng changed type of interaction between the protein and fluorescent probe. I
ntroduction of a antihypoxant, antioxidant, or actoprotector has a positive
effect on the condition of the liver and serum albumins system: The studie
d indices are nearly completely normalized.