Copper introduction changes superoxide dismutase and glutathione peroxidase activities, lipid peroxidation, and content of trace elements in organs and tissues

Chronic application of various copper concentrations on the skin decreases endogenous levels of iron, zinc, and copper in the serum. Single introducti on of disperse copper positively correlates with the level of the oxidation products and Fe/Zn ratio in the liver. Single introduction of ionic and el ectron-neutral copper induces phased changes in superoxide dismutase and gl utathione peroxidase activities. Positive correlation between activities of these enzymes points to efficient control of O-2-radicals, dismutation pro ducts, and hydroperoxides level by the antioxidant enzymes in animal tissue s treated with copper.