Upregulation of p53 protein in rat heart subjected to a transient occlusion of the coronary artery followed by reperfusion

Authors
Xie, ZL Koyama, T Abe, K Fujii, Y Sawa, H Nagashima, K
Citation
Zl. Xie et al., Upregulation of p53 protein in rat heart subjected to a transient occlusion of the coronary artery followed by reperfusion, JPN J PHYSL, 50(1), 2000, pp. 159-162
Citations number
10
Categorie Soggetti
Physiology
Journal title
JAPANESE JOURNAL OF PHYSIOLOGY
ISSN journal
0021521X → ACNP
Volume
50
Issue
1
Year of publication
2000
Pages
159 - 162
Database
ISI
SICI code
0021-521X(200002)50:1<159:UOPPIR>2.0.ZU;2-R
Abstract
The accumulation of p53 protein in cardiomyocyte nuclei was immunohistochem ically demonstrated by the pronounced staining of p53 antibody in 4 h-reper fused ventricular tissue after a 45-min coronary occlusion. The occurrence of apoptosis in the reperfused ventricular tissue was evidenced by positive TUNEL staining and DNA laddering on agarose gels.