POXVIRUS PREPARATION CONPIND INITIATES PRODUCTION OF THE MAJOR INFLAMMATORY MEDIATORS IL-1-ALPHA AND TNF-ALPHA IN HUMAN WHOLE-BLOOD AND IN BLOOD MONONUCLEAR CELL-CULTURES

Authors
AHNE W MAYR A
Citation
W. Ahne et A. Mayr, POXVIRUS PREPARATION CONPIND INITIATES PRODUCTION OF THE MAJOR INFLAMMATORY MEDIATORS IL-1-ALPHA AND TNF-ALPHA IN HUMAN WHOLE-BLOOD AND IN BLOOD MONONUCLEAR CELL-CULTURES, Comparative immunology, microbiology and infectious diseases, 20(2), 1997, pp. 139-145
Citations number
27
Categorie Soggetti
Immunology,"Veterinary Sciences",Microbiology
Journal title
Comparative immunology, microbiology and infectious diseases → ACNP
ISSN journal
01479571
Volume
20
Issue
2
Year of publication
1997
Pages
139 - 145
Database
ISI
SICI code
0147-9571(1997)20:2<139:PPCIPO>2.0.ZU;2-5
Abstract
The poxvirus preparation CONPIND initiated the production of the two m ajor inflammatory mediators interleukin-1 alpha (IL-1 alpha) and tumou r necrosis factor-alpha (TNF-alpha) in whole blood and in blood mononu clear cell cultures of man at 37 degrees C within 12-48 h. The release of the cytokines followed a dose-efficacy curve. High levels of IL1-a lpha (up to 810 pg/ml) and TNF-alpha (up to 533 pg/ml) were determined by sandwich enzyme-linked immunosorbent assay.