PREVALENCE OF CAMPYLOBACTER-ASSOCIATED DIARRHEA AMONG PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS

We performed a cross-sectional study at an outpatient AIDS clinic to a ssess the prevalence of Campylobacter species in stool specimens from 201 consecutive patients infected with human immunodeficiency virus (H IV). We characterized campylobacters phenotypically and genetically by using primers for the group of common species (i.e., C. jejuni, C. co li, C. lari, and C. upsaliensis) and far most individual uncommon spec ies. We performed cultures with use of a membrane filter technique on nonselective blood agar and found that Campylobacter species were the most frequent enteropathogenic bacteria: the organisms were recovered from 7 (16%) of 43 patients with diarrhea and 5 (3%) of 158 patients w ithout diarrhea (P =.001). We isolated only one campylobacter with use of conventional culture techniques on selective media. Phenotypic cha racterization of 10 campylobacter strains resulted in the misidentific ation of four isolates. C. upsaliensis was the most frequently isolate d species, followed by C. jejuni and C. coli. Two strains could not be identified with the available primers. Two of 12 Campylobacter strain s were resistant to erythromycin, and two were resistant to ciprofloxa cin. We conclude that Campylobacter species other than C. jejuni can f requently be detected in the stools of HIV-infected patients and that these organisms could be associated with diarrhea.