OROPHARYNGEAL CANDIDIASIS IN PATIENTS WITH AIDS - RANDOMIZED COMPARISON OF FLUCONAZOLE VERSUS NYSTATIN ORAL SUSPENSIONS

A total of 167 human immunodeficiency virus (HIV)-infected patients wi th oropharyngeal candidiasis were randomly assigned to receive 14 days of therapy with liquid suspension fluconazole (100 mg once daily) or liquid nystatin (500,000 U four times daily). At day 14, 87% of the fl uconazole-treated patients were clinically cured, as opposed to 52% in the nystatin-treated group (P <.001), Fluconazole eradicated Candida organisms from the oral flora in 60%, vs, a 6% eradication rate with n ystatin (P <.001), The fluconazole group had fewer relapses noted on d ay 28 (18%, vs, 44% in the nystatin group; P <.001), This relapse diff erence no longer existed by day 42. Fluconazole oral suspension as a s ystemic therapy was more effective than liquid nystatin as a topical t herapy in the treatment of oral candidiasis in HIV-infected patients a nd provided a longer disease-free interval before relapse.