Therapeutic options in dementia

Dementia is the final common path of various pathogenetic mechanisms that m ay lead to a number of different clinical forms, with primary degenerative and vascular dementias accounting for more than 80% of cases. Dementia is a complex clinical condition that includes cognitive, personality, and behav ioral changes. Therefore a therapeutic approach to dementia should be based from the beginning on a comprehensive intervention plan, both pharmacologi cal and nonpharmacological. This should not be aimed at obtaining a complet e (impossible) recover but at achieving the best day-to-day management of a chronic, progressive, disabling disease involving numerous domains and sho wing impairments with varying rates of progression. Deterioration in functi onal abilities of daily living has a major impact on the quality of life of those suffering from dementia, and this is a critical predictor for instit utionalization. Increasingly necessary for optimizing intervention strategi es are studies to: (a) measure changes in functional abilities over the cou rse of dementia (namely Alzheimer's disease), (b) evaluate the relationship between functional abilities and cognition, and (c) quantify the effect of various therapeutic approaches on functional decline. Symptomatic drugs af fecting cognitive abilities and psychoactive drugs for behavioral disturban ces should be considered. For the cognitive domain positive results have be en obtained with acetylcholinesterase inhibitors. Among the psychoactive dr ugs indicated for behavioral disorders, significant improvement in terms of both efficacy and tolerability can be expected from the use of new antipsy chotic drugs.