Insulin-like growth factor serum concentrations reflect insufficient growth in a hypoplastic infant with partial trisomy 9q in the 12(th) week of life

Authors
Hubler, A Seidel, J Kauf, E Schramm, D Beensen, V Heller, A Liehr, T Zintl, F
Citation
A. Hubler et al., Insulin-like growth factor serum concentrations reflect insufficient growth in a hypoplastic infant with partial trisomy 9q in the 12(th) week of life, J PED END M, 13(4), 2000, pp. 445-450
Citations number
27
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
ISSN journal
0334018X → ACNP
Volume
13
Issue
4
Year of publication
2000
Pages
445 - 450
Database
ISI
SICI code
0334-018X(200004)13:4<445:IGFSCR>2.0.ZU;2-D
Abstract
This report presents changes of IGFs and IGFBPs in a female infant with par tial trisomy 9q in the 12(th) week of life, Studying deficient growth in th is hypoplastic infant (birth weight 1405 g, birth length 36 cm) with dysmor phic features, the following changes in IGFs and IGFBPs were detected (mu g /l): IGF-I: 26.5 vs 48.1 in healthy infants; IGF-II: 420 vs 728; IGFBP-2: 9 31 vs 524; IGFBP3: 800 vs 1070, This demonstrates that IGFs and IGFBPs may reflect individual insufficient growth even at this early age.