R. Tiguert et al., Patients with abnormal ultrasound of the prostate but normal digital rectal examination should be classified as having clinical stage T2 tumors, J UROL, 163(5), 2000, pp. 1486-1490
Purpose: The current TNM staging system classifies prostate tumors with abn
ormal transrectal ultrasound but normal digital rectal examination as clini
cal stage T2. However, most urologists consider these tumors as clinical st
age Tie due to the perceived inaccuracy of transrectal ultrasound in clinic
al staging. To determine the role of transrectal ultrasound in the clinical
staging of prostate cancer we evaluated the pathological stage and disease
-free survival of patients undergoing radical prostatectomy who had tumor d
etected by needle biopsy because of elevated serum prostate specific antige
n with or without transrectal ultrasound abnormalities. Materials and
Methods: Between 1991 and 1996, 738 patients underwent radical retropubic p
rostatectomy as monotherapy for clinically localized prostate cancer. Patie
nts were classified into group 1-normal digital rectal examination and tran
srectal ultrasound (138), group 2-normal digital rectal examination but abn
ormal transrectal ultrasound (366) and group 3 -abnormal digital rectal exa
mination (234), We compared pathological parameters and disease-free-surviv
al among the 3 groups.
Results: Tumors were organ confined in 61%, 42% and 41% of patients in grou
ps 1, 2 and 3, respectively (p = 0.0001). Overall disease-free survival was
80% with a mean followup of 68 months. Disease recurred in 8%, 22% and 25%
of patients in groups 1, 2 and 3, respectively (p = 0.007). Group 1 had be
tter disease-free survival compared to groups 2 and 3 (p = 0.003 and p = 0.
002, respectively), and there was no difference in disease-free survival be
tween groups 2 and 3 (p = 0.39).
Conclusions: We provide evidence to support the use of transrectal ultrasou
nd findings in the clinical staging system for prostate cancer. Patients wi
th normal digital rectal examination, elevated serum prostate specific anti
gen and abnormal transrectal ultrasound should be considered as having clin
ical stage T2 disease.