Thrombosis of the internal jugular vein is a rare entity with the potential
for serious consequences. Most of the reported cases of jugular venous thr
ombosis have occurred in the presence of an indwelling venous catheter, an
established hypercoagulable state, or in association with head and neck sep
sis. This report presents a case of a patient in whom jugular venous thromb
osis developed during the first trimester of pregnancy after in vitro ferti
lization. Thromboembolism in these circumstances can be related to a condit
ion known as the ovarian hyperstimulation syndrome. The presentation of sev
ere neck pain in pregnant women, especially in those who have undergone ass
isted reproduction procedures, should prompt evaluation by duplex scan to e
valuate the jugular veins for thrombosis. Anticoagulation is the treatment
of choice.