M. Ohmori et al., The functions of circulatory polymorphonuclear leukocytes in diabetic patients with and without diabetic triopathy, LIFE SCI, 66(19), 2000, pp. 1861-1870
We determined circulatory polymorphonuclear leukocytes (PMN) functions of s
uperoxide anion production: adhesion and aggregation in 38 type 2 diabetic
patients with and without diabetic triopathy. Tumor necrosis factor (TNF)-a
lpha-stimulated superoxide production and N-formylmethionyl-leucyl-phenylal
anine (FMLP)-stimlated aggregation in diabetic patients with triopathy were
significantly greater than those in diabetics without triopathy. The more
diabetic complications existed, the more TNF-alpha-stimulated superoxide wa
s produced by PMN. These results suggest that the activated PMN contributes
to a progression of diabetic triopathy in type 2 diabetic patients.