Autocrine interferon-beta stimulation augments nitric oxide production by mouse macrophage J774A.1 cells infected with herpes simplex virus type 1

Authors
Fujioka, N Ohashi, K Ikeda, M Kurimoto, M
Citation
N. Fujioka et al., Autocrine interferon-beta stimulation augments nitric oxide production by mouse macrophage J774A.1 cells infected with herpes simplex virus type 1, MICROB IMMU, 44(4), 2000, pp. 283-287
Citations number
29
Categorie Soggetti
Microbiology
Journal title
MICROBIOLOGY AND IMMUNOLOGY
ISSN journal
03855600 → ACNP
Volume
44
Issue
4
Year of publication
2000
Pages
283 - 287
Database
ISI
SICI code
0385-5600(2000)44:4<283:AISANO>2.0.ZU;2-3
Abstract
The pathogenic roles of nitric oxide (NO) ire mouse models have been report ed for herpes simplex virus type 1 (HSV-1)-induced pneumonia as well as end otoxin shock. We compared the mechanism of NO production induced by HSV-1 w ith that induced by lipopolysaccharide (LPS) using a mouse macrophage cell line, J774A.1. Both HSV-1 and LPS induced NO production as well as antivira l activity, which were attenuated by anti-interferon (IFN)-beta treatment. These results suggest that autocrine IFN-beta plays a role in NO release by J774A.1 cells stimulated with HSV-1 or LPS.