Two patients, one with insulinoma and one with Gushing's syndrome, are pres
ented. Biochemical evaluation readily suggested the correct diagnosis. Duri
ng radiologic imaging, the anatomic abnormality giving rise to these diseas
es, i.e. a pancreatic islet cell tumor, and an adrenal adenoma, at first we
re mistakenly interpreted as an accessory spleen on the basis of specific c
omputed tomography and magnetic resonance imaging appearances. The insulino
ma was identified as such during laparotomy, whereas additional jodo-choles
terol scintigraphy revealed the real nature of the lesion in the patient wi
th Gushing's syndrome. Both patients were operated successfully. (C) 2000 E
lsevier Science BN. All rights reserved.