Polyphosphorylation and non-enzymatic template-directed ligation of oligonucleotides

Authors
Gao, K Orgel, LE
Citation
K. Gao et Le. Orgel, Polyphosphorylation and non-enzymatic template-directed ligation of oligonucleotides, ORIGIN LIFE, 30(1), 2000, pp. 45-51
Citations number
20
Categorie Soggetti
Experimental Biology
Journal title
ORIGINS OF LIFE AND EVOLUTION OF THE BIOSPHERE
ISSN journal
01696149 → ACNP
Volume
30
Issue
1
Year of publication
2000
Pages
45 - 51
Database
ISI
SICI code
0169-6149(200001)30:1<45:PANTLO>2.0.ZU;2-3
Abstract
Oligonucleotide 5'-polyphosphates are formed under potentially prebiotic co nditions from oligonucleotide 5'-phosphates and sodium trimetaphosphate. Ol igonucleotides activated as polyphosphates undergo template-directed ligati on. We believe that these reactions could have produced longer oligonucleot ide products from shorter substrates under prebiotic conditions.