Jv. Siebers et al., Converting absorbed dose to medium to absorbed dose to water for Monte Carlo based photon beam dose calculations, PHYS MED BI, 45(4), 2000, pp. 983-995
Current clinical experience in radiation therapy is based upon dose computa
tions that report the absorbed dose to water, even though the patient is no
t made of water but of many different types of tissue. While Monte Carlo do
se calculation algorithms have the potential for higher dose accuracy, they
usually transport particles in and compute the absorbed dose to the patien
t media such as soft tissue, lung or bone. Therefore, for dose calculation
algorithm comparisons, or to report dose to water or tissue contained withi
n a bone matrix for example, a method to convert dose to the medium to dose
to water is required. This conversion has been developed here by applying
Bragg-Gray cavity theory. The dose ratio for 6 and 18 MV photon beams was d
etermined by computing the average stopping power ratio for the primary ele
ctron spectrum in the transport media. For soft tissue, the difference betw
een dose to medium and dose to water is approximately 1.0%, while For corti
cal bone the dose difference exceeds 10%. The variation in the dose ratio a
s a function of depth and position in the field indicates that for photon b
eams a single correction factor can be used for each particular material th
roughout the held for a given photon beam energy. The only exception to thi
s would be for the clinically non-relevant dose to air. Pre-computed energy
spectra for Co-60 to 24 MV are used to compute the dose ratios for these p
hoton beams and to determine an effective energy for evaluation of the dose
ratio.