Valproate induced hypersensitivity syndrome

BACKGROUND: Drug-induced hypersensitivity syndrome is an uncommon but poten tially life-threatening idiosyncratic drug reaction. It is usually due to a romatic anticonvulsants. We report the second case induced by sodium valpro ate, a non-aromatic anticonvulsant. CASE REPORT: A 28-year-old woman was treated with sodium valproate for 5 we eks. She suddenly developed a generalized maculo-papulous eruption with fev er, node enlargement, hypereosinophilia and altered liver function. DISCUSSION: Drug-induced hypersensitivity is rarely induced by valproic add . She time course and positive patch tests using the diluted drug establish the diagnosis.