Pathogenesis of myasthenia gravis

Myasthenia gravis is a neuromuscular, autoimmune, and acquired disturbance characterized! by weakness and fatigue of skeletal muscles. During the past two decades, remarkable progress has been made in the understanding of mya sthenia gravis, and the new knowledge has been applied directly to the clin ical diagnosis and treatment of this formerly severe disease. Myasthenia gr avis is undoubtedly the most thoroughly understood of all human autoimmune diseases and has served as a model for the elucidation of mechanisms underl ying other autoimmune disorders. In this review we mention the most importa nt physiopathological aspects and its application in the clinic practice.