Polymorphism of the angiotensinogen gene T174 variant in Siberian populations

The level of T174M polymorphism of the angiotensinogen gene (AGT) was studi ed for the first time in Siberian populations. The frequency of allele M wa s found to be 7% in Russians, 6% in Tuvinians, and 4% in Buryats. In the Mo ngoloid population of Siberia (Tuvinians and Buryats), the genotypic freque ncies deviated from Hardy-Weinberg equilibrium (P < 0.05). The studied poly morphism of the AGT gene determined in Siberian populations was compared wi th that of other ethnic groups in the world population, and genetic distinc tions were estimated. Only the Buryat population was found to differ signif icantly from the French, English, and Chinese in the frequency of allele M. No association between the T174M polymorphism of the AGT gene and patholog ical pregnancy (gestosis) was revealed in Buryat women.