Polymorphism of the D11S2008 locus of the catalase gene region in muscovites with non-insulin-dependent diabetes mellitus complicated by hypertensionand coronary heart disease

The allele and genotype frequency distributions of the D11S2008 tetranucleo tide microsatellite linked with the catalase (CAT) gene were compared betwe en patients with non-insulin-dependent diabetes mellitus (NIDDM) with (n = 72) and without (n = 82) coronary heart disease (CHD), and between NIDDM pa tients with normal arterial tension (n = 82) and with arterial hypertension (n = 42). In total, eight alleles were found. The alleles varied in length from 120 to 148 bp and included from 15 to 22 tetranucleotide repeats. The groups did not differ in D11S2008 allele and genotype frequencies; the onl y exception was that the frequency of genotype 18/19 in patients with CHD ( 31.9%) was significantly higher than in the controls (18.3%). Thus, the D11 S2008 polymorphic locus located in proximity to the catalase gene proved to be weakly associated with CHD, but not associated with arterial hypertensi on, in NIDDM patients. Genotype 18/19 was associated with a higher risk of CHD.