Tetralone esters as intermediates for the synthesis of podophyllotoxin derivatives via cyclopropanation of chalcones

Authors
Nanjundaswamy, N Shashikanth, S Anjanamurthy, C Rai, KML
Citation
N. Nanjundaswamy et al., Tetralone esters as intermediates for the synthesis of podophyllotoxin derivatives via cyclopropanation of chalcones, SYN COMMUN, 30(7), 2000, pp. 1179-1191
Citations number
9
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
30
Issue
7
Year of publication
2000
Pages
1179 - 1191
Database
ISI
SICI code
0039-7911(2000)30:7<1179:TEAIFT>2.0.ZU;2-2
Abstract
Cyclopropyl eater (8a-f) were synthesized by the cyclopropanation of chalco nes (7a-e) in dry benzene using powdered sodium in 80-85% yield. Preparatio n of tetralone ester (4a-e), an intermediate for the synthesis of podophyll otoxin derivatives by Lewis acid (SnCl4) catalyzed cyclization of(8a-e) is also described here.