Simultaneous detection of S and R captopril using sequential injection analysis

A simultaneous detection sequential injection analysis (SIA) system is prop osed for the determination of S and R captopril using a potentiometric, ena ntioselective membrane electrode based on maltodextrin (DE = 14-17) for the assay of S-captopril and an amperometric biosensor for the assay of R-capt opril. The proposed SIA system can be utilized reliably for the on-line sim ultaneous detection of the enantiomers in the synthesis process at a rate o f 38 samples per hour in the following linear concentration ranges: 100-100 0 nmol/l (R-captopril) and 1-1000 mu mol/l (S-captopril) with a RSD better than 0.009% (n = 10). (C) 2000 Elsevier Science B.V. All rights reserved.