Circadian rhythms of hypophysiothyroid hormones secretion in patients withbronchial asthma

Aim. To examine circadian rhythms of hypophysiothyroid system in patients w ith bronchial asthma and effects of exogenic glucocorticoids on thyroid fun ction. Materials and methods. Free T3, T4 and TTH were measured in plasma using im munochemiluminescence in 16 patients with nonallergic bronchial asthma runn ing a severe course. The plasma samples were taken each 6 hours for 48 hour s. Results. In patients with severe bronchial asthma (SBA) thyroid functional activity changed. Production of T3 increased while that of T4 dropped at ni ght. TTH concentration rhythm for 24 hours was like that in healthy subject s. Glucocorticoids induced no significant changes in circadian rhythms of h ypophysiothyroid system in SBA patients. Conclusion. In SBA functional activity of the hypophysiothyroid system chan ges with rearrangement of hormonal production at night.