Y. Zhang et Jw. Herndon, Selective remote functionalization of alkyl side chains in the coupling ofFischer carbene complexes with conjugated enediynes, TETRAHEDRON, 56(15), 2000, pp. 2175-2182
The reactions of various enediyne derivatives with Fischer carbene complexe
s has been examined. In most cases, benzofuran derivatives featuring a func
tionalized side chain were produced as a result of the coupling reaction. R
eactions performed in chlorobenzene produced mostly this class of products.
The major product was usually the alkene derivative, although in the prese
nce of chlorine atom sources, chloride derivatives were also observed. (C)
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