Neomarinone, and new cytotoxic marinone derivatives, produced by a marine filamentous bacterium (actinomycetales)

Neomarinone (1), a novel metabolite possessing a new sesquiterpene- and pol yketide-derived carbon skeleton, and several derivatives, 3-5, of the marin one class of naphthoquinone antibiotics, were isolated from the fermentatio n broth of a taxonomically-novel marine actinomycete (strain #CNH-099). The structures of the new compounds were determined by comprehensive NMR and m ass spectral analyses. Neomarinone (1) and several of the marinone derivati ves were shown to be moderately cytotoxic toward human cancer cells in in v itro testing. (C) 2000 Elsevier Science Ltd. All rights reserved.