Ih. Hardt et al., Neomarinone, and new cytotoxic marinone derivatives, produced by a marine filamentous bacterium (actinomycetales), TETRAHEDR L, 41(13), 2000, pp. 2073-2076
Neomarinone (1), a novel metabolite possessing a new sesquiterpene- and pol
yketide-derived carbon skeleton, and several derivatives, 3-5, of the marin
one class of naphthoquinone antibiotics, were isolated from the fermentatio
n broth of a taxonomically-novel marine actinomycete (strain #CNH-099). The
structures of the new compounds were determined by comprehensive NMR and m
ass spectral analyses. Neomarinone (1) and several of the marinone derivati
ves were shown to be moderately cytotoxic toward human cancer cells in in v
itro testing. (C) 2000 Elsevier Science Ltd. All rights reserved.