Enantiomeric deoxy-L-nucleotides stabilize a Z-forming DNA decanucleotide

Authors
Vichier-Guerre, S Santamaria, F Rayner, B
Citation
S. Vichier-guerre et al., Enantiomeric deoxy-L-nucleotides stabilize a Z-forming DNA decanucleotide, TETRAHEDR L, 41(13), 2000, pp. 2101-2104
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
13
Year of publication
2000
Pages
2101 - 2104
Database
ISI
SICI code
0040-4039(20000327)41:13<2101:EDSAZD>2.0.ZU;2-1
Abstract
Two contiguous pairs of enantiomeric 2'-deoxy-1-ribonucleotides have been i ncorporated in a 5-methyl-CG alternating decadeoxyribonucleotide duplex. Da ta from circular dichroism and UV melting experiments indicate that the two base-pair long enantio-domain within the duplex was able to stabilize a Z- DNA-like conformation. (C) 2000 Elsevier Science Ltd. All rights reserved.