Structure of argifin, a new chitinase inhibitor produced by Gliocladium sp.

Authors
Shiomi, K Arai, N Iwai, Y Turberg, A Kolbl, H Omura, S
Citation
K. Shiomi et al., Structure of argifin, a new chitinase inhibitor produced by Gliocladium sp., TETRAHEDR L, 41(13), 2000, pp. 2141-2143
Citations number
2
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
13
Year of publication
2000
Pages
2141 - 2143
Database
ISI
SICI code
0040-4039(20000327)41:13<2141:SOAANC>2.0.ZU;2-C
Abstract
A new chitinase inhibitor, named argifin, was isolated from the cultured br oth of a fungal strain Gliocladium sp. FTD-0668. Argifin was a water-solubl e cyclic pentapeptide, and its structure was elucidated as cyclo(N-omega-(N -methylcarbamoyl)-L-arginyl-N-methyl-L-phenylalanyl-beta-L-aspartyl-beta-L- aspartyl-D-alanyl). The IC50 value of argifin against blowfly (Lucilia cupr ina) chitinase was 3.7 mu M. (C) 2000 Elsevier Science Ltd. All rights rese rved.