A convenient route to N-alkyl-2-tributylstannyl-pyrrolidines involving reductive amination

Authors
Ashweek, NJ Coldham, I Vennall, GP
Citation
Nj. Ashweek et al., A convenient route to N-alkyl-2-tributylstannyl-pyrrolidines involving reductive amination, TETRAHEDR L, 41(13), 2000, pp. 2235-2237
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
13
Year of publication
2000
Pages
2235 - 2237
Database
ISI
SICI code
0040-4039(20000327)41:13<2235:ACRTNI>2.0.ZU;2-9
Abstract
A new and convenient method for the formation of N-alkyl-2-tributylstannyl- pyrrolidines from N-Boc-2-tributylstannyl-pyrrolidine has been developed. T he procedure uses N-Boc deprotection, followed by rapid base wash and reduc tive amination with an aldehyde and NaBH3CN in nitromethane. (C) 2000 Elsev ier Science Ltd. All rights reserved.