Use of a scintillant-containing macroporous resin in both solid phase synthesis and subsequent on-bead scintillation-based analysis

A chemically-functionalised scintillant-containing macroporous resin has be en used successfully in a two stage solid phase organic synthesis. The seco nd step in this synthesis involved the covalent attachment of a tritiated a cetate group to the resin. The resultant radiolabelled scintillant-containi ng resin beads scintillate spontaneously and with high efficiency due to th e dose proximity of the tritium atoms to the scintillant molecules within t he beads. (C) 2000 Elsevier Science Ltd. All rights reserved.