VARIOUS APPROACHES TO THE USE OF CETYL-2-AMINO-4-HYDROXY-1,3-PENTADIENECARBONITRILE IN HETEROCYCLIC SYNTHESIS

Two approaches to the use of cetyl-2-amino-4-hydroxy-1,3-pentadienecar bonitrile (1) in heterocyclic synthesis are considered. A method for p reparing 3-acetyl-4-amino-5-cyano-2-methylpyridine directly from 1 and N,N-dimethylformamide dimethylacetal (DMF DMA) was proposed, together with a synthetic route to hydroxyphenyl)-8-cyano-5-hydroxy-4-methylqu inoline based an the transformation of hydroxyvinyl ketone 1 into its diphenylboron chelate and condensation of the latter with DMF DMA.