Non-invasive diagnosis of ischemic brain damage after cardiopulmonary resuscitation in dogs by using transcranial Doppler ultrasonography

We have attempted to identify whether it is possible to utilize transcrania l Doppler ultrasonography to evaluate the brain damage that occurs after re suscitation from 3 min (control group) and 12 min (damage group) of cardiac arrest in dogs. In this study we used transcranial Doppler ultrasonography to follow the basilar arterial flow and middle cerebral arterial flow for 180 min following the induction of cardiac arrests. Two abnormal waveform p atterns (the "to-and-fro" and "diastolic no-flow" patterns) were found in a ll dogs in the damage group whereas abnormal waveforms were not detected in the control group. Pathological diagnosis revealed that, compared with the control group, the damage group recognized ischemic alteration at the leve l of the hippocampus and caudate nucleus. In conclusion, this study shows that the basilar arterial flow of observed with transcranial Doppler ultrasonography may be use for the prediction of outcome and the diagnosis of brain damage in the dog.