DETECTION AND CHARACTERIZATION OF LEISHMANIA IN TISSUES OF PATIENTS WITH POST KALA-AZAR DERMAL LEISHMANIASIS USING A SPECIFIC MONOCLONAL-ANTIBODY

Authors
ISMAIL A KHARAZMI A PERMIN H ELHASSAN AM
Citation
A. Ismail et al., DETECTION AND CHARACTERIZATION OF LEISHMANIA IN TISSUES OF PATIENTS WITH POST KALA-AZAR DERMAL LEISHMANIASIS USING A SPECIFIC MONOCLONAL-ANTIBODY, Transactions of the Royal Society of Tropical Medicine and Hygiene, 91(3), 1997, pp. 283-285
Citations number
14
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
Journal title
Transactions of the Royal Society of Tropical Medicine and Hygiene → ACNP
ISSN journal
00359203
Volume
91
Issue
3
Year of publication
1997
Pages
283 - 285
Database
ISI
SICI code
0035-9203(1997)91:3<283:DACOLI>2.0.ZU;2-S
Abstract
Sections from skin lesions and draining lymph nodes of patients with p ost kala-azar dermal leishmaniasis were examined using an immunoperoxi dase method and a monoclonal antibody directed against Leishmania dono vani. Parasites were detected in 22 of 25 biopsies (88%). In parallel sections stained by haematoxylin and eosin, parasites were detected in only 5 of 25 of the biopsies (20%). The demonstration of whole parasi tes or parasite antigen is diagnostic.