Nt. Chinh et al., SHORT COURSES OF OFLOXACIN FOR THE TREATMENT OF ENTERIC FEVER, Transactions of the Royal Society of Tropical Medicine and Hygiene, 91(3), 1997, pp. 347-349
Citations number
19
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
Typhoid fever continues to be a major public health problem in tropica
l countries, exacerbated in recent years by the spread of multi-drug r
esistant strains of Salmonella typhi. Short treatment courses of fluor
oquinolones are effective, and have the advantage of reduced cost and
increased compliance, but the optimal length of treatment is unknown.
In an open, randomized comparison, 107 adults with uncomplicated enter
ic fever (95 of whom had positive blood cultures for S. typhi and 5 fo
r S. paratyphi) were treated with oral ofloxacin, 15 mg/kg/d for 2 d o
r 10 mg/kg/d for 3 d. Mean fever clearance times were the same in the
2 treatment groups (97 h). There were 7 treatment failures, one in the
2 d group and 6 in the 3 d group (P = 0.07). Three of the 5 patients
infected with nalidixic acid resistant strains of S. typhi had treatme
nt failures, compared with 4 of 90 with nalidixic acid sensitive isola
tes (P < 0.0001; relative risk 13.5, 95 % confidence interval 4.1-45 %
). Treatment with ofloxacin for 2 or 3 d is equally effective in adult
s with uncomplicated enteric fever caused by nalidixic acid sensitive
strains of S. typhi. The epidemiology and management of nalidixic acid
resistant typhoid needs further investigation.