Multiple myeloma presenting high fever and high serum levels of lactic dehydrogenase, CRP, and interleukin-6

Authors
Murakami, H Takada, S Hatsumi, N Yokohama, A Saitoh, T Uchiumi, H Maehara, T Matsushima, T Tsukamoto, N Morita, K Tamura, J Sawamura, M Karasawa, M
Citation
H. Murakami et al., Multiple myeloma presenting high fever and high serum levels of lactic dehydrogenase, CRP, and interleukin-6, AM J HEMAT, 64(1), 2000, pp. 76-77
Citations number
8
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF HEMATOLOGY
ISSN journal
03618609 → ACNP
Volume
64
Issue
1
Year of publication
2000
Pages
76 - 77
Database
ISI
SICI code
0361-8609(200005)64:1<76:MMPHFA>2.0.ZU;2-G
Abstract
Two myeloma patients presented high fever with no signs or data indicating infection at diagnosis or relapse. Both patients had plasmablastic myeloma, and serum levels of lactic dehydrogenase (LDH) and CRP were extremely high . Plasmablastic morphology, high LDH, and CRP were recognized as poor progn ostic factors, indicating a fulminant phase of multiple myeloma. Interleuki n-6 (IL-6) was only high In measured cytokines. We proposed that IL-6 cause d high fever and induced the fulminant phase In these 2 cases. Am. J. Hemat ol. 64:76-77, 2000. (C) 2000 Wiley-Liss, Inc.