Embryonal rhabdomyosarcoma and chromosomal breakage in a newborn infant with possible Dubowitz syndrome

We report on a newborn girl with Dubowitz syndrome (DS) and embryonal rhabd omyosarcoma (ERMS), with multiple chromosomal breakage (MCB). The tumor was resected but recurred in a few months, resulting in the infant's death. Ma lignancy and chromosomal breakage have been reported previously in DS. Howe ver, ERMS has not been reported among the malignant tumors diagnosed in DS. To our knowledge, concurrence of DS, ERMS, and MCB has not been reported p reviously. This is the first observation of DS in the Arab ethnic group. Am . J. Med, Genet. 92:107-110, 2000. (C) 2000 Wiley-Liss, Inc.