On-line assay of S-captopril using an amperometric biosensor/sequential injection system

An automated system for the enantiopurity test of S-captopril based on the concept of sequential injection analysis (SIA) with an amperometric biosens or (based on L-amino acid oxidase (L-AAOD)) as detector is described. The p roposed system is fully computerised and is suitable for the on-line monito ring of S-captopril at a sampling rate of 80 samples per hour with an RSD < 0.22% in the linear range between 0.05 and 1.50 mu-mol/l. The detection lim it is 16 nmol/l. (C) 2000 Elsevier Science B.V. All rights reserved.