Examination of structural changes of polymeric amino acid-based surfactants on enantioselectivity: Effect of amino acid order, steric factors, and number and position of chiral centers
E. Billiot et Im. Warner, Examination of structural changes of polymeric amino acid-based surfactants on enantioselectivity: Effect of amino acid order, steric factors, and number and position of chiral centers, ANALYT CHEM, 72(8), 2000, pp. 1740-1748
In this study, a large number of polymeric chiral surfactants were examined
and their performances in terms of enantiomeric resolution compared for a
variety of chiral analytes, The surfactants investigated in this study incl
ude all possible dipeptide combinations of the L-form of alanine, valine, l
eucine, and the achiral amino acid glycine (except glycine-glycine). Also i
ncluded in this study were the single amino acid surfactants of alanine, va
line, and leucine as well as the single chiral center dipeptide surfactant
poly(sodium undecyl-L-leucine-beta-alanine) (poly L-SUL beta A). Several di
fferent aspects of polymeric dipeptide surfactants, as they pertain to chir
al separations, are examined. Some of the factors investigated in this repo
rt include the effect of position and number of chiral centers, amino acid
order, and steric effects.