Characterization of a novel transcription factor binding to the regulatoryregions of the human pro-alpha 1(I) collagen gene

Authors
Zhao, MK Pretorius, PJ de Vries, WN
Citation
Mk. Zhao et al., Characterization of a novel transcription factor binding to the regulatoryregions of the human pro-alpha 1(I) collagen gene, ARCH BIOCH, 376(2), 2000, pp. 281-287
Citations number
40
Categorie Soggetti
Biochemistry & Biophysics
Journal title
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
ISSN journal
00039861 → ACNP
Volume
376
Issue
2
Year of publication
2000
Pages
281 - 287
Database
ISI
SICI code
0003-9861(20000415)376:2<281:COANTF>2.0.ZU;2-4
Abstract
We have identified a novel transcription factor TGP (TG Binding Protein) th at binds to the consensus sequence 5'-TGTGGGGTGG-3' in the promoter and int ron of the human pro-alpha 1(I) collagen gene. This recognition sequence, o r sequences closely resembling these sequences, was also identified in the pro-alpha 1(I) and pro-alpha 2(I) collagen genes of other species. Competit ion experiments revealed that TGP is related to but distinguishable from th e Ap4/5 family of transcription factors and that it can be separated from A p4/5 according to size. (C) 2000 Academic Press.