Malignant adenomyoepithelioma of the breast with malignant proliferation of epithelial and myoepithelial elements - A case report and review of the literature

Malignant adenomyoepithelioma of the breast is a rare lesion characterized by malignant proliferation of epithelial and myoepithelial cells that show characteristic histologic and immunohistochemical features. Eleven cases ha ve been reported, 4 of which showed evidence of distant metastasis. The aut hors report a case of malignant adenomyoepithelioma in the axillary tail of a 71-year-old woman, one of the oldest patients described so far, and revi ew the literature. Malignancy in the current case was evidenced by the pres ence of local invasion, high mitotic rate, and severe cytologic atypia. The tumor was associated with adenosis and lobular adenomyoepithelial hyperpla sia. Malignant adenomyoepithelioma is a rare neoplasm, diagnosable by light microscopy and immunohistochemistry. To date, it has only been reported in women, who ranged in age from 26 to 76 years. Metastases have only been do cumented in tumors 2.0 cm in diameter or larger.