Is mitochondrial DNA involved in mouse behavioral laterality?

The genetic effect of mitochondrial DNA (mtDNA) on behavioral laterality wa s investigated in a quartet of strains of laboratory mice congenic for mtDN A. The pattern of restriction of mtDNA differed in NZB/BINJ and CBA/H mice. Their respective congenics for mtDNA were developed until the 22nd generat ion. This quartet was tested under three independent conditions involving f ore- and hind paw preference or performance (laterality tests) and body ori entation. Evidence for the implication of mtDNA was observed on direction o f laterality in two test conditions and on degree of laterality in the thre e test conditions.