Do the embryonic assumptions for the reconstruction of the myelocele exist?

The myelocele that usually affects the lumbar and sacral segments of the sp inal cord occurs from the 4th week of the development of the embryo due to the failure of neural tube to close. While the dorsal horns of the spinal c ord are absent, the motoneurons of the ventral horns develop and their axon s grow to the periphery. The neural fibers of the spinal ganglia also take part on the peripheral nerves. The neural cells and fibers of the spinal ga nglia arise from the neural crest independently on the neural tube, but the ir afferent connections to the spinal cord cannot be realized from the reas on of myelocele. The result is a weak paralysis, a loss of sensibility and the trophic breakdowns. Therapeutically, it is possible to correct the spin al cord defect by a transplantation of embryonic neural tissue to replace t he missing dorsal spinal horns.