Isoxazolines and isoxazoles as Factor Xa inhibitors

Authors
Pruitt, JR Pinto, DJ Estrella, MJ Bostrom, LL Knabb, RM Wong, PC Wright, MR Wexler, RR
Citation
Jr. Pruitt et al., Isoxazolines and isoxazoles as Factor Xa inhibitors, BIOORG MED, 10(8), 2000, pp. 685-689
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
8
Year of publication
2000
Pages
685 - 689
Database
ISI
SICI code
0960-894X(20000417)10:8<685:IAIAFX>2.0.ZU;2-W
Abstract
3,4,5-Trisubstituted isoxazolines (2) and isoxazoles (3) were prepared and evaluated for their in vitro and in vivo antithrombotic efficacy. They were compared to 3,5,5-trisubstituted isoxazolines (1) for Factor Xa selectivit y and potency. They were also compared in an arterio-venous (A-V) shunt mod el of thrombosis. (C) 2000 DuPont Pharmaceuticals Company. Published by Els evier Science Ltd. All rights reserved.