Antitumor agents. Part 202: Novel 2 '-amino chalcones: Design, synthesis and biological evaluation

Authors
Xia, Y Yang, ZY Xia, P Bastow, KF Nakanishi, Y Lee, KH
Citation
Y. Xia et al., Antitumor agents. Part 202: Novel 2 '-amino chalcones: Design, synthesis and biological evaluation, BIOORG MED, 10(8), 2000, pp. 699-701
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
8
Year of publication
2000
Pages
699 - 701
Database
ISI
SICI code
0960-894X(20000417)10:8<699:AAP2N2>2.0.ZU;2-O
Abstract
New 4',5',2,3.4-substituted 2'-amino chalcones were synthesized and evaluat ed for cytotoxicity against a panel of human tumor cell lines. Several comp ounds displayed significant cytotoxicity. The most promising lead molecule (10) also had high activity toward multi-drug resistant KB-VIN, and ovarian 1A9 cell lines. 2'-Amino chalcones demonstrated significantly increased an titumor activity compared with the corresponding chalcones, while, the epox ide derivatives generally showed greatly reduced activity. (C) 2000 Elsevie r Science Ltd. All rights reserved.