Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

Authors
Jin, S Kim, JS Sim, SP Liu, A Pilch, DS Liu, LF LaVoie, EJ
Citation
S. Jin et al., Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors, BIOORG MED, 10(8), 2000, pp. 719-723
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
8
Year of publication
2000
Pages
719 - 723
Database
ISI
SICI code
0960-894X(20000417)10:8<719:HBDATI>2.0.ZU;2-8
Abstract
A series of 2'-heterocyclic derivatives of 5-phenyl-2,5'-1H-bibenzimidazole s were evaluated for topoisomerase I poisoning activity and cytotoxicity. T opo I poisoning activity was associated with 2'-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the int eratomic distances between such hydrogen atoms and the heteroatoms on the a djacent benzimidazole influence activity. (C) 2000 Elsevier Science Ltd. Al l rights reserved.