Cyclodextrin-peptide hybrid as a hydrolytic catalyst having multiple functional groups

Authors
Tsutsumi, H Hamasaki, K Mihara, H Ueno, A
Citation
H. Tsutsumi et al., Cyclodextrin-peptide hybrid as a hydrolytic catalyst having multiple functional groups, BIOORG MED, 10(8), 2000, pp. 741-743
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
8
Year of publication
2000
Pages
741 - 743
Database
ISI
SICI code
0960-894X(20000417)10:8<741:CHAAHC>2.0.ZU;2-R
Abstract
A designed cyclodextrin-peptide hybrid, which has multiple functional group s on its alpha-helix peptide backbone, has been synthesized as a catalyst f or eater hydrolysis. Kinetic study revealed that the carboxylate group play s a key role in this system. (C) 2000 Elsevier Science Ltd. All rights rese rved.