Guanylpiperidine peptidomimetics: Potent and selective bis-cation inhibitors of factor Xa

Authors
Tamura, SY Levy, OE Uong, TH Reiner, JE Goldman, EA Ho, JZ Cohen, CR Bergum, PW Nutt, RF Brunck, TK Semple, JE
Citation
Sy. Tamura et al., Guanylpiperidine peptidomimetics: Potent and selective bis-cation inhibitors of factor Xa, BIOORG MED, 10(8), 2000, pp. 745-749
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
8
Year of publication
2000
Pages
745 - 749
Database
ISI
SICI code
0960-894X(20000417)10:8<745:GPPASB>2.0.ZU;2-9
Abstract
A novel series of rigid P-3-guanylpiperidine peptide mimics 3-14 was design ed as potential factor Xa and prothrombinase inhibitors. Incorporation into a P-2-gly-P-1-argininal motified to highly potent and selective inhibitors . The synthesis and biological activities of these derivatives are reported herein. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.